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Equity Issuance Costs in Accounts Payable, Accrued Expenses, and Other Long Term Liabilities Equity issuance costs in accounts payable, accrued expenses, and other long-term liabilities Antidilutive Security, Excluded EPS Calculation [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Liabilities Total liabilities Financial Instruments [Domain] Financial Instruments Loss Contingency, Estimate of Possible Loss Contingent payments Restricted Stock [Member] Restricted Common Shares [Member] Restricted Stock [Member] Weighted Average Number of Shares Outstanding, Diluted Diluted weighted-average common shares outstanding Diluted weighted-average common shares outstanding Diluted weighted-average common shares outstanding Securities Act File Number Entity File Number OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Unrealized (loss) gain on marketable securities Cover [Abstract] Total marketable securities, Amortized Cost Available for sale marketable securities amortized cost basis. 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Equity Securities, FV-NI, Unrealized Gain (Loss) Equity Securities, FV-NI, Unrealized Gain (Loss), Total Unrealized (loss) gain recorded on marketable securities Assets [Abstract] Assets Construction in Progress [Member] Construction Work in Process [Member] Increase (Decrease) in Prepaid Expense and Other Assets, Total Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Amortization of Debt Issuance Costs and Discounts Amortization of Debt Issuance Costs and Discounts, Total Amortization of debt issuance costs Document Fiscal Year Focus Document Fiscal Year Focus Borrowings under Guaranteed Investment Agreements Amount of initial purchasers' option to purchase Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Investing activities: Accounts Payable, Current, Total Accounts Payable, Current Accounts payable Equity Securities Available For Sale Unrealized Loss Gain Position Equity securities available for sale unrealized (loss) gain position. 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Corporate Equity Securities [Member] Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Vesting of restricted shares (in shares) Collaboration revenue. 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Laboratory Equipment [Member] Laboratory Equipment [Member] Stamp taxes on issuance of common stock Stamp Taxes On Issuance Of Common Stock Stamp taxes on issuance of common stock Sirius Therapeutics [Member] Sirius Therapeutics. Sirius Therapeutics [Member] Finite-Lived Intangible Assets by Major Class [Axis] Schedule of Debt [Table Text Block] Schedule of Interest Expense Recognized and Effective Interest Rates Cash, Cash Equivalent, and Investment [Table Text Block] Summary of Cash Equivalents and Marketable Securities Recorded at Fair Value Employee Stock [Member] ESPP [Member] Entity Registrant Name Entity Registrant Name Debt Disclosure [Text Block] Debt Amended and Restated Vertex Joint Development and Commercialization Agreement [Member] Amended and restated vertex joint development and commercialization agreement. 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Increase Decrease In Operating Lease Assets And Liabilities Operating lease assets and liabilities Debt Instrument, Face Amount Principal amount Aggregate Face Values Counterparty Name [Domain] Counterparty Name Segment Reporting Information [Line Items] Raju Prasad [Member] Raju Prasad. 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Local Phone Number Local Phone Number Other Liabilities, Current, Total Other Liabilities, Current Other current liabilities Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Total unrecognized compensation expense related to stock options Aggregate estimated gross proceeds Estimated gross proceeds from issuance of common stock. Estimated Gross Proceeds From Issuance Of Common Stock Future Development Regulatory and Sales Milestone Payment Future development regulatory and sales milestone payment. Future development regulatory and sales milestone payment Accounting Policies [Abstract] Threshold trading days Debt Instrument, Convertible, Threshold Trading Days Revenue from Contract with Customer, Excluding Assessed Tax, Total Revenue from Contract with Customer, Excluding Assessed Tax Total revenue Revenue Sirius [Member] Sirius Agreement [Member] Sirius Agreement [Member] Sirius Agreement [Member] Commercial Paper [Member] Commercial Paper [Member] Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Number of remaining common shares available Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Unrecognized compensation expense, remaining weighted-average period for recognition Accrued Professional Fees, Current Professional fees Stock, Class of Stock [Table] Schedule Of Stock By Class [Table] Entity Emerging Growth Company Entity Emerging Growth Company