100000 - Document - Document and Entity Information
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100010 - Statement - Consolidated Balance Sheets
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100020 - Disclosure - Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets (Detail) 2
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100040 - Statement - Consolidated Balance Sheets (Parenthetical)
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100050 - Statement - Consolidated Statements of Operations and Comprehensive Loss
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100060 - Statement - Consolidated Statements of Shareholders' Equity
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100070 - Statement - Consolidated Statements of Shareholders' Equity (Parenthetical)
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100080 - Statement - Consolidated Statements of Cash Flows
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100090 - Statement - Consolidated Statements of Cash Flows (Parenthetical)
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100100 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
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995455 - Disclosure - Organization and Operations
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995465 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation
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995505 - Disclosure - Accrued Expenses
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995525 - Disclosure - Significant Contracts
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995535 - Disclosure - Commitments and Contingencies
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995545 - Disclosure - Share Capital
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995555 - Disclosure - Equity-based Compensation
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995565 - Disclosure - Net Loss Per Share Attributable to Common Shareholders
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995575 - Disclosure - 401 (k) Savings Plan
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995585 - Disclosure - Income Taxes
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995595 - Disclosure - Segment Information
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995605 - Disclosure - Selected Quarterly Financial Data (Unaudited)
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995615 - Disclosure - Related Party Transactions
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995625 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation (Policies)
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995635 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation (Tables)
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995655 - Disclosure - Fair Value Measurement (Tables)
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995665 - Disclosure - Property and Equipment, net (Tables)
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995675 - Disclosure - Accrued Expenses (Tables)
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995685 - Disclosure - Leases (Tables)
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995695 - Disclosure - Share Capital (Tables)
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995705 - Disclosure - Equity-based Compensation (Tables)
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995715 - Disclosure - Net Loss Per Share Attributable to Common Shareholders (Tables)
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995725 - Disclosure - Income Taxes (Tables)
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995735 - Disclosure - Segment Information (Tables)
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995745 - Disclosure - Selected Quarterly Financial Data (Unaudited) (Tables)
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995755 - Disclosure - Organization and Operations - Additional Information (Detail)
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995765 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation - Additional Information (Detail)
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995775 - Disclosure - Summary of Significant Accounting Policies and Basis of Presentation - Schedule of Estimated Useful Lives of Assets (Detail)
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995795 - Disclosure - Marketable Securities - Summary of Cash Equivalents and Marketable Securities Recorded at Fair Value (Detail)
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995805 - Disclosure - Fair Value Measurement - Schedule of Financial Assets Measured at Fair Value on Recurring Basis (Detail)
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995815 - Disclosure - Property and Equipment, net - Summary of Property and Equipment, Net (Detail)
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995825 - Disclosure - Property and Equipment, net - Additional Information (Detail)
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995835 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Detail)
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995845 - Disclosure - Leases - Additional Information (Detail)
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995855 - Disclosure - Leases - Summary of Lease Assets and Liabilities (Detail)
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995865 - Disclosure - Leases - Summary of Operating Lease Costs Included in Research and Development and General and Administrative Expense, as well as Sublease Income (Detail)
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995875 - Disclosure - Leases - Summary of Maturity of Undiscounted Payments Due under Lease Liabilities and Present Value of Those Liabilities (Detail)
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995885 - Disclosure - Leases - Summary of Lease Term and Discount Rate (Detail)
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995895 - Disclosure - Leases - Summary of Cash Paid for Amounts Included in Measurement of Lease Liabilities (Detail)
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995905 - Disclosure - Significant Contracts - Additional Information (Detail)
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995915 - Disclosure - Commitments and Contingencies - Additional Information (Detail)
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995925 - Disclosure - Share Capital - Additional Information (Detail)
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995935 - Disclosure - Equity-based Compensation - Option and Grant Plans - Additional Information (Detail)
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995945 - Disclosure - Equity-based Compensation - Equity-Based Compensation Expense - Additional Information (Detail)
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995955 - Disclosure - Equity-based Compensation - Schedule of Stock-Based Compensation Expense (Detail)
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995965 - Disclosure - Equity-based Compensation - Fair Value of Each Option Issued to Employees Estimated Using Black-Scholes Option-Pricing Model (Detail)
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995975 - Disclosure - Equity-based Compensation - Summary of Stock Option Activity (Detail)
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995985 - Disclosure - Equity-based Compensation - Stock Options - Additional Information (Detail)
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995995 - Disclosure - Equity-based Compensation - Summary of Restricted Stock Activity (Detail)
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996005 - Disclosure - Equity-based Compensation - Restricted Stock - Additional Information (Detail)
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996015 - Disclosure - Equity-based Compensation - Employee Stock Purchase Plan - Additional Information (Detail)
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996035 - Disclosure - 401(k) Savings Plan - Additional Information (Detail)
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996045 - Disclosure - Income Taxes - Schedule of Net Loss Before Income Taxes (Detail)
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996055 - Disclosure - Income Taxes - Schedule of (Provision) Benefit for Income Taxes (Detail)
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996065 - Disclosure - Income Taxes - Schedule of Reconciliation of Income Tax Expense Computed at Statutory Corporate Income Tax Rate to Effective Income Tax Rate (Detail)
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996075 - Disclosure - Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets (Detail)
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996085 - Disclosure - Income Taxes - Additional Information (Detail)
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996095 - Disclosure - Income Taxes - Schedule of Aggregate Changes in Gross Unrecognized Tax Benefits (Detail)
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996105 - Disclosure - Segment Information - Additional Information (Detail)
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996115 - Disclosure - Segment Information - Schedule of Reportable Segment Profit and Loss, Including Significant Expense Categories, Attributable to the Company's Reportable Segment (Details)
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996125 - Disclosure - Segment Information - Schedule of Reportable Segment Profit and Loss, Including Significant Expense Categories, Attributable to the Company's Reportable Segment (Details) (Parenthetical)
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Collaborative Arrangement, Accounting Policy [Policy Text Block]
Collaboration Arrangements
Statement [Line Items]
Statement [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Unrecognized Tax Benefits, Decrease Resulting from Current Period Tax Positions
Decreases for tax positions taken during current period
Maximum potential future payments.
Maximum Potential Future Payments
Maximum potential future payments
Cybersecurity Risk Board of Directors Oversight [Text Block]
Increase (Decrease) in Accounts Receivable
Accounts receivable
Plan Name [Domain]
Plan Name
Incentive from Lessor
Tenant incentives
Twenty twenty Boston lease.
Twenty Twenty Boston Lease [Member]
2020 Boston Lease [Member]
Research and Development, Contract to Perform for Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Non employees.
Non Employees [Member]
Non-Employees [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash, Cash Equivalents and Investments [Table Text Block]
Summary of Cash Equivalents and Marketable Securities Recorded at Fair Value
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Revenue, Remaining Performance Obligation, Amount
Transaction price allocated to remaining performance obligations
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Marketable Security, Unrealized Gain (Loss)
Net unrealized gain on equity securities
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Deferred Tax Assets, Operating Loss Carryforwards, Foreign
Non-US Net operating loss carryforwards
Revenues [Abstract]
Revenue:
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Total unrecognized compensation expense
Collaboration costs
Accrued Collaboration Costs
Accrued collaboration costs.
Number of Operating Segments
Number of operating segments
Share-Based Payment Arrangement, Tranche One [Member]
Vesting Percentage on First Anniversary [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted-Average Exercise Price, Exercisable
Cash, Cash Equivalents, and Marketable Securities [Text Block]
Marketable Securities
US Government-sponsored Enterprises Debt Securities [Member]
Government-sponsored Enterprise Securities [Member]
Shares, Outstanding
Ending balance (in shares)
Beginning balance (in shares)
Other Noncash Income (Expense)
Other non-cash items, net
Other non-cash items, net
Other non-cash items, net
Common Stock Capital Reserved For Future Issuance, Shares Held
Common Stock Capital Reserved For Future Issuance, Shares Held
Capital reserved for future issuance held by the Company and its subsidiaries
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Auditor Name
Acquired in-process research and development
Acquired in - Process Research and Development
Acquired in - Process research and development
Deferred Federal Income Tax Expense (Benefit)
Federal
Fair Value, Inputs, Level 2 [Member]
Level 2 [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Capital Band [Member]
capital band
Capital Band [Member]
Schedule of Stock by Class [Table Text Block]
Schedule of Share Capital
Business combination, consideration transferred
Business Combination, Consideration Transferred
Business Combination, Consideration Transferred, Total
Current Federal, State and Local, Tax Expense (Benefit) [Abstract]
Current income taxes:
Cash equivalents and available for sale debt securities fair value.
Cash Equivalents And Available For Sale Debt Securities Fair Value
Cash equivalents and marketable securities, fair value
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Lessee, Operating Leases [Text Block]
Leases
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Vesting of restricted shares
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Product and Service [Axis]
Product and Service
Investment, Name [Domain]
Investment, Name
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Stamp Taxes Due on Issuance of Common Stock
Stamp taxes due on issuance of common stock.
Stamp taxes due on issuance of common stock
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of non-cash investing and financing activities
Accrued research and development expense current.
Accrued Research And Development Expense Current
Research costs
Employee Stock [Member]
2016 Employee Stock Purchase Plan [Member]
ESPP [Member]
Cybersecurity Risk Management Processes Integrated [Text Block]
Equity [Text Block]
Share Capital
Title and Position [Axis]
Title of Individual
Sale of Stock [Domain]
Sale of Stock
Entity Central Index Key
Entity Central Index Key
Cash Equivalents, at Carrying Value
Cash equivalents, amortized cost
Casebia Therapeutics LLP.
Casebia Therapeutics Llp [Member]
Casebia Therapeutics Limited Liability Partnership [Member]
Common stock registered share capital.
Common Stock Registered Share Capital
Registered share capital
Auditor Opinion [Text Block]
Increase (Decrease) in Operating Capital [Abstract]
Changes in:
Deferred tax liabilities operating lease assets.
Deferred Tax Liabilities Operating Lease Assets
Operating lease assets
Common Stock, Shares, Issued
Common stock, shares issued
Common Stock, Shares, Issued, Total
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Uncertain tax position recognized.
Uncertain Tax Position Recognized
Significant uncertain tax positions
Uncertain tax positions recognized
Uncertain tax positions
Liability for Uncertainty in Income Taxes, Noncurrent
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Quarterly Financial Information [Table Text Block]
Selected Quarterly Financial Data
Patent costs.
Patent Costs Policy Policy [Text Block]
Patent Costs
Income Statement [Abstract]
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Net loss before income taxes
Furniture, fixtures, and other.
Furniture Fixtures And Other [Member]
Furniture, Fixtures, and Other [Member]
Other Comprehensive Income Location [Axis]
Marketable Securities
Marketable securities
Marketable Securities, Total
Marketable securities unrealized loss
Debt Securities, Available-for-Sale, Unrealized Loss Position
Debt Securities, Available-for-Sale, Unrealized Loss Position, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable
Recognized Interest and Penalties Related to Uncertain Tax Positions
Recognized interest and penalties related to uncertain tax positions.
Recognized interest and penalties related to uncertain tax positions
Treasury Stock, Common, Shares
Treasury Stock, shares
Cover [Abstract]
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Basic net (loss) income per common share
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per common share - basic
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance
Decrease in valuation allowance
Lessee, Operating Lease, Option to Extend
Lessee, operating lease, option to extend
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Marketable securities, gross unrealized gains
Operating Expenses [Abstract]
Operating expenses:
Recent accounting pronouncements not yet adopted.
Recent Accounting Pronouncements Not Yet Adopted Policy [Text Block]
New Accounting - Pronouncements Not Yet Adopted
Contract with Customer, Liability, Current
Deferred revenue, current
Current deferred revenue
Document Annual Report
Document Annual Report
Annual rental payment.
Annual Rental Payment
Annual rental payments
Consolidation Items [Domain]
Investments, Debt and Equity Securities [Abstract]
Basis of presentation and use of estimates.
Basis Of Presentation And Use Of Estimates Policy [Text Block]
Basis of Presentation and Use of Estimates
Non-Ex License Agreement [Member]
Non-Ex License Agreement [Member]
Non-Ex License Agreement.
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Stock-based compensation expense
Lease expiration year.
Lease Expiration Year
Lease expiration year
Effective income tax rate reconciliation nondeductible expense impact of deferred rate change.
Effective Income Tax Rate Reconciliation Nondeductible Expense Impact Of Deferred Rate Change
Impact of deferred rate change
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Plan Name [Axis]
Plan Name
Segment Reporting [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Shares, Outstanding, Ending Balance
Shares, Outstanding, Beginning Balance
Share-based compensation, options, outstanding
Loss from equity method investments.
Loss From Equity Method Investments [Member]
Loss from Equity Method Investment [Member]
Assets, Current [Abstract]
Current assets:
Common Stock, Capital Shares Reserved for Future Issuance
Registered common shares
Investment Type [Axis]
Investment Type
Deferred Tax Liabilities, Net
Long term deferred taxes, liabilities
Deferred Tax Liabilities, Net, Total
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Entity Address, Country
Entity Address, Country
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Unvested, Weighted-Average Grant Date Fair Value, Cancelled or forfeited
Lease arrangement.
Lease Arrangement [Member]
Lease Arrangement
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Product and Service [Domain]
Product and Service
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive income
Sales agreement with Jefferies LLC.
Sales Agreement With Jefferies L L C [Member]
Sales Agreement With Jefferies LLC [Member]
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Lessee, Operating Lease, Liability, to be Paid, Year Four
2028
Contract with Customer, Liability, Noncurrent
Deferred revenue, non-current
Non-current deferred revenue
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating activities
Fair Value, Recurring [Member]
Recurring Basis [Member]
Vesting [Axis]
Vesting
Common Stock, Par or Stated Value Per Share
Common stock, par value
Common shares, nominal value
Contingencies and commitments.
Contingencies And Commitments [Line Items]
Contingencies And Commitments [Line Items]
Outstanding Options [Member]
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized (loss) gain on marketable securities
Contract with Customer, Liability
Contract liabilities
Contract with Customer, Liability, Total
Taxes Payable, Current
Accrued tax liabilities
Taxes Payable, Current, Total
Statement of Cash Flows [Abstract]
Counterparty Name [Axis]
Counterparty Name
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Marketable securities.
Marketable Securities [Member]
Marketable Securities [Member]
Entity [Domain]
Entity
Deferred Tax Assets, Other
Other deferred tax assets
Restricted Stock [Member]
Restricted Stock [Member]
Equity Components [Axis]
Equity Components
Entity Address, Address Line One
Entity Address, Address Line One
Accounting analysis, defer option amount.
Accounting Analysis, Defer Option Amount
Defer option amount
Employee-related Liabilities, Current
Payroll and employee-related costs
Employee-related Liabilities, Current, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Unvested, Shares, Granted
Stock units granted
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Two thousand nineteen at-the-market offering.
Two Thousand Nineteen At Market Offering [Member]
2019 ATM [Member]
Computer Equipment [Member]
Computer Equipment [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Leasehold improvements paid directly by landlord.
Leasehold Improvements Paid Directly by Landlord
Leasehold improvements paid directly by landlord
Equity Option [Member]
Stock Option [Member]
Nonoperating Income (Expense)
Total other income, net
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities not Include in Computation of Net Loss per Share
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Deferred tax assets operating lease liabilities.
Deferred Tax Assets Operating Lease Liabilities
Operating lease liabilities
Debt securities available for sale securities remaining maturity greater than three year.
Debt Securities Available For Sale Securities Remaining Maturity Greater Than Three Year
Available-for-sale debt securities remaining maturities greater than thirty months
Accrued stamp taxes
Accrued stamp taxes.
Accrued Stamp Taxes
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Unvested, Shares, Ending Balance
Unvested, Shares, Beginning Balance
Performance stock units unvested
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research credits
Entity Voluntary Filers
Entity Voluntary Filers
Amendment Flag
Amendment Flag
Accounting Standards Update 2016-02 [Member]
ASC 842 [Member]
Current Income Tax Expense (Benefit)
Total current income taxes
Current Income Tax Expense (Benefit), Total
Current Federal Tax Expense (Benefit)
Federal
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Non-current operating lease liabilities
Domestic Tax Jurisdiction [Member]
U.S. Domestic Federal [Member]
Corporate Debt Securities [Member]
Corporate Debt Securities [Member]
Additional Paid in Capital, Common Stock
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Two thousand and nineteen Lease.
Two Thousand And Nineteen Lease [Member]
2019 Lease [Member]
Payable of stamp taxes related to securities.
Payable Of Stamp Taxes Related To Securities
Payable of stamp taxes related to securities
Deferred Tax Liabilities, Property, Plant and Equipment
Depreciation
Accounts Receivable
Receivable [Policy Text Block]
Net loss
Net loss
Orphan drug credit carryforwards.
Orphan Drug Credit Carryforwards [Member]
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Shares, Exercised
Exercise of vested options, net of issuance costs (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Share based compensation, number of shares eligible to receive
Share based compensation, number of shares eligible to receive
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Shares, Exercisable
Research and Development Expense [Member]
Research and Development [Member]
Research and Development Expense [Member]
Two thousand twenty one at market offering.
Two Thousand Twenty One At Market Offering [Member]
2021 ATM [Member]
Accrued license fees current.
Accrued License Fees Current
Licensing fees
Equity Component [Domain]
Equity Component
Equity issuance costs in accounts payable and accrued expenses.
Equity Issuance Costs In Accounts Payable And Accrued Expenses
Equity issuance costs in accounts payable and accrued expenses
Statistical Measurement [Domain]
Statistical Measurement
Stock purchased during period shares employee stock purchase plan.
Stock Purchased During Period Shares Employee Stock Purchase Plan
Purchase of common stock under ESPP (in shares)
Document Financial Statement Error Correction Flag
Document Financial Statement Error Correction [Flag]
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
General and administrative expense
Collaboration Expense
Collaboration Expense
Collaboration expense, net
Deferred Federal, State and Local, Tax Expense (Benefit) [Abstract]
Deferred income taxes:
Cash equivalents and available for sale debt securities gross unrealized gains before tax.
Cash Equivalents And Available For Sale Debt Securities Gross Unrealized Gains Before Tax
Cash equivalents and marketable securities, gross unrealized gains
Other Nonoperating Income (Expense)
Other (expense) income
Other Nonoperating Income (Expense), Total
Other income, net
Deferred State and Local Income Tax Expense (Benefit)
State
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Share-based compensation, options, contractual life
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Components of Deferred Tax Liabilities [Abstract]
Deferred tax liabilities:
Treasury Shares [Member]
Treasury Stock, Common [Member]
Cybersecurity Risk Management Processes Integrated [Flag]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss of joint venture
Net (loss) income
Net loss
Segment net income
Operating Lease, Payments
Operating cash flows used in operating leases
Vertex Pharmaceuticals Inc and Casebia.
Vertex Pharmaceuticals Inc And Casebia [Member]
Vertex and Casebia [Member]
Retirement Benefits [Text Block]
401(k) Savings Plan
Percentage of net profit and net losses.
Percentage Of Net Profit And Net Losses
Percentage of net profits and net losses
Payables and Accruals [Abstract]
Deferred Tax Liabilities, Other
Other deferred tax liabilities
Operating lease non-cash items.
Operating Lease Non Cash Items [Abstract]
Operating lease non-cash items:
Consolidation Items [Axis]
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Prepaid expenses and other current assets
Restricted Cash, Noncurrent
Restricted cash
Restricted cash
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Class of Stock [Domain]
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Collaborative Arrangement Disclosure [Text Block]
Significant Contracts
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of (Provision) Benefit for Income Taxes
Antidilutive Securities [Axis]
Antidilutive Securities
Corporate Bond Securities [Member]
Bond [Member]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Deferred Foreign Income Tax Expense (Benefit)
Foreign
Entity Interactive Data Current
Entity Interactive Data Current
Marketable Securities [Table]
Marketable Securities [Table]
March Two Thousand and Twenty Three Diabetes Agreements [Member]
March two thousand and twenty three diabetes agreements.
March 2023 Diabetes Agreements [Member]
Cost excluded from license agreement
Cost Excluded from License Agreement
Cost Excluded from License Agreement
Accounting Standards Update [Domain]
Accounting Standards Update
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Accruals and reserves
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Unvested, Weighted-Average Grant Date Fair Value, Vested
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Statement of Financial Position Location, Balance [Axis]
Balance Sheet Location
Statistical Measurement [Axis]
Statistical Measurement
Cash equivalents and available for sale debt securities gross unrealized losses before tax.
Cash Equivalents And Available For Sale Debt Securities Gross Unrealized Losses Before Tax
Cash equivalents and marketable securities, gross unrealized losses
Research Tax Credit Carryforward [Member]
Research and Development [Member]
Operating Lease, Cost
Operating lease costs
Assets, Fair Value Disclosure
Total
Available For Sale Marketable Securities
Available for sale marketable securities.
Total marketable securities, fair value
Lease, Cost
Net lease cost
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Summary of Maturity of Undiscounted Payments Due under Lease Liabilities and Present Value of Those Liabilities
Other Comprehensive Income (Loss) [Member]
Comprehensive Loss [Member]
Commercial Paper [Member]
Commercial Paper [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of shares available for future grant
Milestone payment receivable.
Milestone Payment Receivable
Milestone payment receivable
Basis of Presentation and Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies and Basis of Presentation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Unvested, Weighted-Average Grant Date Fair Value, Granted
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation expense, remaining weighted-average period for recognition
Two thousand twenty at market offering.
Two Thousand Twenty At Market Offering [Member]
2020 ATM [Member]
Effective income tax rate reconciliation statutory permanent differences.
Effective Income Tax Rate Reconciliation Statutory Permanent Differences
Statutory to U.S. GAAP permanent differences
Deferred Tax Assets, Net
Long term deferred taxes, assets
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses
Ownership [Domain]
Ownership
Statement of Income Location, Balance [Axis]
Income Statement Location
Canton of Zug.
Canton Of Zug [Member]
Canton of Zug [Member]
Assets
Total assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Right-of-use assets increased through lease modifications and reassessments.
Right Of Use Assets Increased Through Lease Modifications And Reassessments
Right-of-use assets increased through lease modifications and reassessments
Two thousand and fifteen lease.
Two Thousand And Fifteen Lease [Member]
2015 Lease [Member]
Equity Securities Available For Sale Unrealized Gain Position
Equity securities available for sale unrealized gain position.
Marketable equity securities unrealized gain
Current Foreign Tax Expense (Benefit)
Foreign
Payments to Acquire Equity Securities, FV-NI
Investment in equity securities
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Deferred Tax Liabilities, Gross, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Unvested, Shares, Vested
New Accounting Pronouncements, Policy [Policy Text Block]
New and Recently Adopted Accounting Pronouncements
Entity Address, City or Town
Entity Address, City or Town
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive (Loss) Income [Member]
Equity [Abstract]
Cash equivalents gross unrealized losses before tax.
Cash Equivalents Gross Unrealized Losses Before Tax
Cash equivalents, gross unrealized losses
Auditor Location
Payments of Stock Issuance Costs
Issuance costs
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Reconciliation of Effective Income Tax Rate
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Unvested, Shares, Cancelled or forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Non Rule 10b5 1 Arr Modified Flag
Non-Rule 10b5-1 Arrangement Modified
Non rule 10b 51 arr modified flag.
Redeemable Preferred Stock [Member]
Redeemable Preferred Stock [Member]
Compensation Related Costs [Abstract]
Depreciation
Depreciation expense
Depreciation, Total
Depreciation
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Total fair value of restricted stock vested
Other Assets, Fair Value Disclosure
Other non-current assets
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Proceeds From Letter Agreement
Amount of cash inflow from a letter agreement.
Proceeds from letter agreement
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock-based compensation
Other Rate Items
Effective Income Tax Rate Reconciliation, Tax Credit, Other, Percent
Share-Based Payment Arrangement [Text Block]
Equity-based Compensation
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Construction in Progress [Member]
Construction Work in Process [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of shares authorized
Number of authorized for issuance
Current State and Local Tax Expense (Benefit)
State
Operating Lease, Weighted Average Discount Rate, Percent
Operating leases, weighted-average discount rate
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Accrued interest or penalties related to uncertain tax positions
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Schedule of estimated useful lives of assets.
Schedule Of Estimated Useful Lives Of Assets Table [Text Block]
Schedule of Estimated Useful Lives of Assets
Common Stock Registered Share Capital Value
Common stock registered share capital value
Common stock share capital value
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Lease expiration month and year.
Lease Expiration Month And Year
Lease expiration, month and year
Grant [Member]
Grant Revenue [Member]
Fair Value Disclosures [Abstract]
Equity issuance costs.
Equity Issuance Costs
Equity issuance costs
Entity Public Float
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Cancelled or forfeited
Stock Issued During Period, Value, New Issues
Issuance of common shares, net of issuance costs
Issuance of common shares, value
Deferred Tax Assets, Net of Valuation Allowance
Net deferred tax assets
Stock Issued During Period, Value, Stock Options Exercised
Exercise of vested options, net of issuance costs
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Liabilities, Current [Abstract]
Current liabilities:
Document Type
Document Type
Stock purchased during period value employee stock purchase plan.
Stock Purchased During Period Value Employee Stock Purchase Plan
Purchase of common stock under ESPP
Accounting Standards Update [Axis]
Accounting Standards Update
Cash, cash equivalents and marketable securities.
Cash Cash Equivalents And Marketable Securities
Cash, cash equivalents and marketable securities
Segment Reporting Reconciliation of Operating Profit (Loss) Adjustments
Segment reporting reconciliation of perating Prpofit (loss) adjustments.
Adjustments or reconciling items
Title of 12(b) Security
Title of 12(b) Security
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Deferred finance costs, share lending arrangement, issuance costs.
Deferred Finance Costs, Share Lending Arrangement, Issuance Costs
Deferred Finance Costs, Share Lending Arrangement, Issuance Costs
Marketable securities maturity period.
Marketable Securities Maturity Period
Marketable securities maturity period
Statement of Financial Position Location, Balance [Domain]
Balance Sheet Location
Lessee, Operating Lease, Liability, to be Paid, Year Five
2029
Lease, Cost [Table Text Block]
Summary of Operating Lease Costs Included in Research and Development and General and Administrative Expense, as well as Sublease Income
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Statement of Stockholders' Equity [Abstract]
Document Fiscal Period Focus
Document Fiscal Period Focus
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of stock options exercised
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research credit
Research and Development Expense
Research and development
Research and development expense
Research and Development Expense, Total
Number of additional renewal terms.
Number Of Additional Renewal Terms
Number of additional renewal terms
Options granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Shares, Granted
Accounting Standards Update and Change in Accounting Principle [Table Text Block]
Impact of Adoption ASC 842 on the Financial Statements
Asset Class [Domain]
Asset Class
Property, Plant and Equipment, Gross
Total property and equipment, gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
2015 Collaboration Agreement.
Two Thousand And Fifteen Collaboration Agreement [Member]
2015 Collaboration Agreement [Member]
Lessee, Leases [Policy Text Block]
Leases
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Fair Value of Each Option Issued to Employees Estimated Using Black-Scholes Option-Pricing Model
Operating Segments [Member]
Operating Segments [Member]
SWITZERLAND
Switzerland [Member]
Marketable securities unrealized gain
Debt Securities Available For Sale Unrealized Gain Position
Debt securities available for sale unrealized gain position.
Research milestone payment
Research Milestone Payment
Research milestone payment
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Marketable securities unrealized loss, more than twelve months
Financial Instruments [Domain]
Financial Instruments
UNITED KINGDOM
United Kingdom [Member]
Vertex Pharmaceuticals Incorporated and its certain subsidiaries.
Vertex Pharmaceuticals Incorporated And Its Certain Subsidiaries [Member]
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member]
Vertex [Member]
Sale of Stock [Axis]
Sale of Stock
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investing activities
Investments [Domain]
Investments
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Summary of Restricted Stock Activity
Marketable Securities, Current
Marketable securities
Marketable Securities, Current, Total
Revenue from Contract with Customer, Excluding Assessed Tax
Total revenue
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Income Tax Disclosure [Text Block]
Income Taxes
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decreases for tax positions taken in prior periods
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of Income Tax Expense Computed at Statutory Corporate Income Tax Rate to Effective Income Tax Rate
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Ownership [Axis]
Ownership
Purchase of in-process research and development
Payments to Acquire in Process Research and Development
Option and grant plans.
Option And Grant Plans [Member]
Option and Grant Plans [Member]
Credit Facility [Domain]
Accounting Analysis, defer option specified cost.
Accounting Analysis, Defer Option Specified Cost
Defer option specified cost
Finite-Lived Intangible Assets, Net
Intangible assets, net
Finite-Lived Intangible Assets, Net, Total
Finite-Lived Intangible Assets, Net, Beginning Balance
Finite-Lived Intangible Assets, Net, Ending Balance
Lease renewal term under each extension option.
Lease Renewal Term Under Each Extension Option
Lease renewal term under each extension option
Other Accrued Liabilities, Current
Other
Liabilities and Equity [Abstract]
Liabilities and Shareholders’ Equity
Document Period End Date
Document Period End Date
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Effective Income Tax Rate Reconciliation, Percent
Effective income tax rate
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive securities not include in computation of net loss per share
Cash equivalents fair value.
Cash Equivalents Fair Value
Cash equivalents, fair value
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Accrued Liabilities, Current
Accrued expenses
Total
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description
(Provision) benefit for income taxes
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Total income tax (provision) benefit
Provision (benefit) for income taxes
Provision (benefit) for income taxes
Hemoglobinopathy Agreements [Member]
Hemoglobinopathy Agreements [Member]
Hemoglobinopathy agreements.
Components of Deferred Tax Assets [Abstract]
Deferred tax assets:
Trading Symbol
Trading Symbol
Equity, Attributable to Parent
Ending balance
Beginning balance
Total shareholders’ equity
Accrued intellectual property costs current.
Accrued Intellectual Property Costs Current
Intellectual property costs
Deferred Tax Assets, Gross
Total deferred tax assets
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Other Liabilities, Noncurrent
Other non-current liabilities
Other Liabilities, Noncurrent, Total
Derivative Instrument [Axis]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units [Member]
Restricted Stock Unit [Member]
Related Party Transactions [Abstract]
Variable Lease, Cost
Variable lease costs
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Cybersecurity Risk Management, Strategy, and Governance [Table]
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Schedule of Stock-Based Compensation Expense
Defined Contribution Plan, Employer Discretionary Contribution Amount
Company contributions toward the plan
Deferred Income Tax Expense (Benefit)
Total deferred income taxes
Deferred Income Tax Expense (Benefit), Total
Other Comprehensive Income Location [Domain]
Total marketable securities, gross unrealized gains
Available For Sale Marketable Securities Accumulated Gross Unrealized Gain Before Tax
Available for sale marketable securities accumulated gross unrealized gain before tax.
Geographical [Axis]
Geographical
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Marketable securities, gross unrealized losses
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Total unrecognized compensation expense related to stock options
Leases [Abstract]
Collaborative Arrangement [Member]
Collaborative Arrangement [Member]
2019 Collaboration Agreement [Member]
Operating Loss carryforwards expiration period.
Operating Loss Carryforwards Expiration Period
Operating loss carryforwards expiration period
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Available For Sale Marketable Securities Amortized Cost Basis
Available for sale marketable securities amortized cost basis.
Total marketable securities, amortized cost
Total marketable securities, amortized cost
Research and development contract arrangement reimbursements received.
Research And Development Contract Arrangement Reimbursements Received
Reimbursements from research and license agreements
Vertex Pharmaceuticals Inc.
Vertex Pharmaceuticals Inc [Member]
Vertex Pharmaceuticals Inc [Member]
Class of Stock [Line Items]
Class of Stock [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Security Exchange Name
Security Exchange Name
Counterparty Name [Domain]
Counterparty Name
Unvested restricted common shares.
Unvested Restricted Common Shares [Member]
Unvested Restricted Common Shares [Member]
Operating expenses
Total operating expenses
Operating Expenses
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Class of Stock [Axis]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Legal Entity [Axis]
Legal Entity
Fair Value Disclosures [Text Block]
Fair Value Measurement
Lessee, Operating Lease, Liability, to be Paid, Year Three
2027
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value
Maximum [Member]
Maximum [Member]
Maximum [Member]
Liabilities and Equity
Total liabilities and shareholders’ equity
Operating lease assets
Net lease assets
Operating lease, right-of-use asset
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
Share-based compensation, options, vested
Retirement Benefits [Abstract]
Diluted net (loss) income per common share
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per common share - diluted
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Two thousand and nineteen sublease.
Two Thousand And Nineteen Sublease [Member]
2019 Sublease [Member]
Dividends
Dividends declared and paid
Dividends, Total
Liabilities
Total liabilities
Research and Development [Abstract]
Payments of stamp taxes related to securities.
Payments Of Stamp Taxes Related To Securities
Payments of stamp taxes related to securities
Rule 10b51 arr modified [flag]
Rule 10b51 arr modified flag.
Rule 10b5-1 Arrangement Modified
Common Stock, Voting Rights
Common stock, voting rights
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Assets, Current
Total current assets
Net Cash Provided by (Used in) Investing Activities
Net cash (used in) provided by investing activities
Two thousand and sixteen sublease.
Two Thousand And Sixteen Sublease [Member]
2016 Sublease [Member]
Issuance of common shares, net of issuance costs (in shares)
Issuance of common shares
Common shares sold
Cash [Member]
Cash [Member]
Unrecognized Tax Benefits
Balance at end of year
Balance at beginning of year
Unrecognized tax benefits, gross
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Nondeductible expenses
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Cash equivalents gross unrealized gain before tax.
Cash Equivalents Gross Unrealized Gains Before Tax
Cash equivalents, gross unrealized gains
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Share-based compensation, vesting period
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lessee, operating lease, existence of option to extend
Cash paid for amounts included in measurement of lease liabilities.
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Cash paid for amounts included in measurement of lease liabilities:
Entity Filer Category
Entity Filer Category
Up-front payment received.
Up Front Payment Received
Up-front payment received
Lease assets.
Lease Assets
Total lease assets
Property, Plant and Equipment [Abstract]
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Organization and Operations
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Unrecognized tax benefits would favorably impact the effective tax rate if recognized
Payments to Acquire Marketable Securities
Payments to Acquire Marketable Securities, Total
Purchases of marketable debt securities
Nonoperating Income (Expense) [Abstract]
Other income
Current Fiscal Year End Date
Current Fiscal Year End Date
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Present value adjustment
Share-Based Payment Arrangement, Noncash Expense
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation
Stock-based compensation expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding Balance
Entity Registrant Name
Entity Registrant Name
Lessee, Operating Sublease, Existence of Option to Extend [true false]
Lessee, operating sublease, existence of option to extend
Quarterly Financial Information [Text Block]
Selected Quarterly Financial Data (Unaudited)
Number of reportable segments
Number of Reportable Segments
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Earnings Per Share [Text Block]
Net Loss Per Share Attributable to Common Shareholders
Two thousand and eighteen stock option and incentive plan.
2018 Plan [Member]
Entity Emerging Growth Company
Entity Emerging Growth Company
Accounting Standards Update 2016-13 [Member]
ASC 326 [Member]
Money Market Funds [Member]
Money Market Funds [Member]
Other Liabilities, Current
Other current liabilities
Other Liabilities, Current, Total
Basic weighted-average common shares outstanding
Weighted Average Number of Shares Outstanding, Basic, Total
Basic
Weighted Average Number of Shares Outstanding, Basic
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
Variable Interest Entities
Vesting [Domain]
Vesting
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Increases for tax positions taken in prior periods
Rental payments period under lease arrangement.
Rental Payments Period Under Lease Arrangement
Rental payments period
Common Stock, Shares Authorized
Common stock, shares authorized
Authorized share capital
Property, Plant and Equipment, Useful Life
Estimated useful lives of assets
Sublease Income
Sublease income
Sublease income
Proceeds from issuance of common shares
Proceeds from issuance of common shares, net of issuance costs
Proceeds from Issuance of Common Stock
Proceeds from Sale and Maturity of Marketable Securities
Proceeds from Sale and Maturity of Marketable Securities, Total
Maturities of marketable debt securities
Fair Value, Inputs, Level 1 [Member]
Level 1 [Member]
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Accounts payable and accrued expenses
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Weighted-Average Exercise Price, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted-average exercise price
Weighted-Average Exercise Price, Granted
Financial Instrument [Axis]
Financial Instrument
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Share Attributable to Common Shareholders
General and Administrative Expense [Member]
General and Administrative [Member]
General and Administrative Expense [Member]
Share-Based Payment Arrangement [Abstract]
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-lived Assets
Common shares employee equity incentive plans
Deferred Compensation Arrangement with Individual, Common Stock Reserved for Future Issuance
Cybersecurity Risk Role of Management [Text Block]
Lessee, weighted average remaining lease term and weighted average discount rate.
Lessee Weighted Average Remaining Lease Term And Weighted Average Discount Rate Table [Text Block]
Summary of Lease Term and Discount Rate
Debt Securities, Available-for-Sale
Marketable securities, fair value
Debt Securities, Available-for-sale, Total
Accounting Policies [Abstract]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Income Tax Disclosure [Abstract]
Marketable Securities, Noncurrent
Marketable securities, non-current
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increases for tax positions taken during current period
Equity, Attributable to Parent [Abstract]
Shareholders’ equity:
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Lessee, lease assets and liabilities.
Lessee Lease Assets And Liabilities Table [Text Block]
Summary of Lease Assets and Liabilities
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Restricted Cash
Statement [Table]
Statement [Table]
Segment Reporting, Policy [Policy Text Block]
Segment Information
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment, Net
Cash equivalents and available for sale debt securities amortized cost basis.
Cash Equivalents And Available For Sale Debt Securities Amortized Cost Basis
Cash equivalents and marketable securities, amortized cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Share-based compensation, requisite service period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term, Vested or expected to vest
Revenue from Contract with Customer, Including Assessed Tax
Revenue
Securities Act File Number
Entity File Number
Segment Reporting Disclosure [Text Block]
Segment Information
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
(Decrease) increase in cash
Current payment due
Current Payment Due
Current payment due.
Earnings Per Share [Abstract]
Net (loss) income per common share:
Two thousand eighteen at-the-market offering.
Two Thousand Eighteen At Market Offering [Member]
2018 ATM [Member]
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock-based compensation
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State income tax, net of federal benefit
Other Receivables
Other receivables
Statement of Financial Position [Abstract]
Average share price per share.
Average Share Price Per Share
Average issue price of common shares
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
IPO [Member]
IPO [Member]
Entity Incorporation, Date of Incorporation
Company incorporation date
Operating Income (Loss)
Loss from operations
Loss from operations
Shares Issued, Price Per Share
Common shares price per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Letter of Credit [Member]
Letter of Credit [Member]
Entity Shell Company
Entity Shell Company
Accrued Professional Fees, Current
Professional fees
Entity Tax Identification Number
Entity Tax Identification Number
Assets [Abstract]
Assets
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value of Financial Instruments
Cash Collateral for Borrowed Securities
Prepaid expenses and other current assets
Letters of credit secured by cash held in restricted depository account
Entity Current Reporting Status
Entity Current Reporting Status
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term, Exercisable
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Common Shares [Member]
Common Shares [Member]
Common Shares [Member]
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, net
Tax credit carryforward expiration year.
Tax Credit Carryforward Expiration Year
Tax credit carryforward, expiration year
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Geographical [Domain]
Geographical
Document Fiscal Year Focus
Document Fiscal Year Focus
Corporate Equity Securities [Member]
Corporate Equity Securities [Member]
Corporate equity securities member.
Non-Cash Adjustment
non-cash adjustment.
Non-cash adjustment
Share-Based Payment Arrangement, Tranche Two [Member]
Vesting Percentage on Second Anniversary [Member]
Framingham lease.
Framingham Lease [Member]
Framingham Lease [Member]
Certificates of Deposit [Member]
Certificates of Deposit [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
Shares, Cancelled or forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Total
Capital Expenditures Incurred but Not yet Paid
Property and equipment purchases in accounts payable and accrued expenses
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Schedule of Aggregate Changes in Gross Unrecognized Tax Benefits
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents and restricted cash, end of period
Cash, cash equivalents and restricted cash, beginning of period
Total
Collaboration revenue.
Collaboration Revenue [Member]
Collaboration Revenue [Member]
Tax Credit Carryforward, Amount
Tax credit carryforward amount
City Area Code
City Area Code
Liabilities, Current
Total current liabilities
Derivative Contract [Domain]
Equity Securities [Member]
Equity Securities [Member]
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Income tax expense at statutory rate
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Laboratory equipment.
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Income Tax Jurisdiction [Axis]
Income Tax Authority
Income Tax, Policy [Policy Text Block]
Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Net Loss Before Income Taxes
Commitments and Contingencies Disclosure [Abstract]
Shares, Issued
Common shares issued
Treasury Stock, Value
Treasury Stock, Value, Total
Treasury Stock, Value, Beginning Balance
Treasury Stock, Value, Ending Balance
Treasury shares, at cost, 170,316 shares at December 31, 2024 and at December 31, 2023
Dr. Katherine High [Member]
Dr. Katherine High [Member]
Dr. Katherine High [Member]
Deferred Tax Asset, Valuation Allowance [Table]
Valuation Allowance [Table]
Debt Securities, Available-for-Sale, Amortized Cost
Marketable securities, amortized cost
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Significant Components of Company's Deferred Tax Assets
Operating Lease, Liability, Current
Operating lease liabilities
Operating lease liabilities, current
Amended and restated vertex joint development and commercialization agreement.
Amended and Restated Vertex Joint Development and Commercialization Agreement [Member]
A&R Vertex JDCA [Member]
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total
Income Tax Jurisdiction [Domain]
Income Tax Authority
Retained Earnings [Member]
Accumulated Deficit [Member]
Prepaid Expenses and Other Current Assets [Member]
Prepaid Expenses and Other Current Assets [Member]
Payments to Acquire Property, Plant, and Equipment
Purchase of property, plant and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Accrued Liabilities, Current [Abstract]
Available For Sale Marketable Securities Accumulated Gross Unrealized Loss Before Tax
Available for sale marketable securities accumulated gross unrealized loss before tax.
Total marketable securities, gross unrealized losses
Total marketable securities, gross unrealized losses
Document Transition Report
Document Transition Report
Lessee, Operating Lease, Liability, to be Paid, Year Two
2026
Uncertain Tax Position Related to Accrued Interest and Penalties
Uncertain tax position related to accrued interest and penalties.
Uncertain tax position related to accrued interest and penalties
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign rate differential
Proceeds from Stock Plans
Received net proceeds
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-Average Exercise Price, Exercised
Restricted Cash Noncurrent [Member]
Restricted Cash Noncurrent [Member]
Restricted Cash Noncurrent [Member]
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations of Credit Risk and Off-balance Sheet Risk
Auditor Firm ID
Minimum [Member]
Minimum [Member]
Minimum [Member]
Common Stock [Member]
Common Shares [Member]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Accrued Expenses
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Aggregate Intrinsic Value, Vested or expected to vest
Investment, Name [Axis]
Investment, Name
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Unvested, Weighted-Average Grant Date Fair Value, Ending Balance
Unvested, Weighted-Average Grant Date Fair Value, Beginning Balance
Valuation Allowance [Line Items]
Valuation Allowance [Line Items]
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Translation and Transactions
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Reconciliation of net loss to net cash used in operating activities:
Contingencies and commitments.
Contingencies And Commitments [Table]
Contingencies And Commitments [Table]
Lessee, Operating Sublease, Option to Extend
Lessee, operating sublease, option to extend
Statement of Income Location, Balance [Domain]
Income Statement Location
Lessee, Operating Lease, Liability, to be Paid, Year One
2025
Other Assets, Noncurrent
Other non-current assets
Other Assets, Noncurrent, Total
Increase (Decrease) in Other Operating Liabilities
Other liabilities, net
Increase (Decrease) in Other Operating Liabilities, Total
Performance Shares [Member]
Performance-Based [Member]
Performance Shares [Member]
Market-based vesting conditions.
Market Based Vesting Conditions [Member]
Market-Based [Member]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Leasehold improvements
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Marketable securities unrealized loss, Less than twelve months
Increase decrease in operating lease assets and liabilities.
Increase Decrease In Operating Lease Assets And Liabilities
Operating lease assets and liabilities
Title and Position [Domain]
Title of Individual
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Domestic
Sale of
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common shares, CHF 0.03 nominal value, 132,477,166 and 126,536,183 shares authorized at December 31, 2024 and December 31, 2023, respectively, 85,912,297 and 80,214,694 shares issued at December 31, 2024 and December 31, 2023, respectively, 85,741,981 and 80,044,378 shares outstanding at December 31, 2024 and December 31, 2023, respectively
Investment Income, Interest
Interest income on investments
Cash and Cash Equivalents, Fair Value Disclosure
Cash and cash equivalents
Lessee, operating lease cash flow payments.
Lessee Operating Lease Cash Flow Payments Table [Text Block]
Lessee, Operating Lease Cash Flow Payments
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Financial Assets Measured at Fair Value on Recurring Basis
Total lease liabilities
Present value of lease liabilities
Net lease liabilities
Operating lease liability
Measurement Frequency [Axis]
Measurement Frequency
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Expenses
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Commitments and Contingencies
Commitments and contingencies (Note 9)
Departing employee.
Departing Employee [Member]
Departing Employee [Member]
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Diluted weighted-average common shares outstanding
Diluted weighted-average common shares outstanding
Diluted
Weighted Average Number of Shares Outstanding, Diluted
Schedule of Reportable Segment Profit and Loss, Including Significant Expense Categories, Attributable to the Company's Reportable Segment
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Lessee, Operating Lease, Renewal Term
Extended term of lease expiration
Shares, Vested and expected to vest
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Lessee, Operating Lease, Liability, to be Paid
Total
Cybersecurity Risk Management Third Party Engaged [Flag]
Lease commencement date.
Lease Commencement Date
Lease commencement date
Entity Small Business
Entity Small Business
Segment Reporting Information [Line Items]
Collaborative arrangement material rights.
Collaborative Arrangement Material Rights [Member]
Collaboration Target Options [Member]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
U.S. federal net operating loss carryforwards
Deferred Tax Liabilities, Intangible Assets
Intangible assets
US Treasury Securities [Member]
US Treasury Securities [Member]
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Proceeds from exercise of options and ESPP contributions, net of issuance costs
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised, Total
Credit Facility [Axis]
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Vesting of restricted shares (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Service [Member]
Service [Member]
Compensation Related Costs, Policy [Policy Text Block]
Equity-Based Compensation Expense
Reconciliation of Revenue from Segments to Consolidated [Table]
Net Cash Provided by (Used in) Financing Activities [Abstract]
Financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price, Outstanding, Ending Balance
Weighted-Average Exercise Price, Outstanding, Beginning Balance
Accounting Standards Update 2019-12 [Member]
ASU 2019-12 [Member]
Net proceeds from transfer
Net Proceeds From Transfer
Net proceeds from transfer.
Liabilities [Abstract]
Liabilities
Asset Class [Axis]
Asset Class
State and Local Jurisdiction [Member]
U.S. Domestic State [Member]
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use assets obtained in exchange for operating lease liabilities
Estimated gross proceeds from issuance of common stock.
Estimated Gross Proceeds From Issuance Of Common Stock
Aggregate estimated gross proceeds
Measurement Frequency [Domain]
Measurement Frequency
Deferred Tax Assets, Valuation Allowance
Less valuation allowance
Deferred Tax Assets, Valuation Allowance, Total
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent, Total
Other comprehensive loss
Fair Value, Inputs, Level 3 [Member]
Level 3 [Member]
Operating Lease, Weighted Average Remaining Lease Term
Operating leases, weighted-average remaining lease term (years)
Quarterly Financial Information Disclosure [Abstract]
Other receivables.
Other Receivables Policy [Text Block]
Other Receivables
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total
Marketable securities unrealized gain
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Accrued property and equipment.
Accrued Property And Equipment
Accrued property and equipment
Short-Term Lease, Cost
Short-term lease costs