Net cash and restricted cash received in connection with the acquisition of Casebia
Net Cash And Restricted Cash Received In Connection With Acquisition Of Controlling Interest
Net cash and restricted cash received in connection with acquisition of controlling interest.
Share-based compensation, vesting period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Segment Information
Segment Reporting, Policy [Policy Text Block]
Maximum potential future payments
Maximum Potential Future Payments
Maximum potential future payments.
Certificates of Deposit [Member]
Certificates of Deposit [Member]
Statutory Accounting Practices, Jurisdiction
Statutory Accounting Practices, Jurisdiction [Domain]
Property, plant and equipment, net
Property, Plant, and Equipment, Fair Value Disclosure
2020 Boston Lease [Member]
Twenty Twenty Boston Lease [Member]
Twenty twenty Boston lease.
Non-Employees [Member]
Non Employees [Member]
Non employees.
Valuation Approach and Technique
Valuation Approach and Technique [Domain]
Research and Development Services [Member]
Research And Development Services [Member]
Research and development services.
Auditor Location
Deferred Revenue, Total
Deferred revenue
Deferred Revenue
Collaboration Target Options Material Rights One [Member]
Collaborative Arrangement Material Rights One [Member]
Collaborative arrangement material rights one.
Operating expenses:
Operating Expenses [Abstract]
Treasury Shares [Member]
Treasury Stock [Member]
Total consideration paid
Consideration Paid Under Collaboration Agreement
Consideration paid under collaboration agreement.
Unrecognized equity method losses in excess of Company's interest
Unrecognized Equity Method Losses In Excess Of Interest
Unrecognized equity method losses in excess of interest.
Asset Class
Asset Class [Domain]
Income (loss) from operations
Loss from operations
Operating Income (Loss)
Percentage sharing of profit (loss) from sale of product
Percentage Sharing Of Profit Loss From Sale Of Products
Percentage sharing of profit (loss) from sale of products.
Entity Emerging Growth Company
Entity Emerging Growth Company
Income Tax Disclosure [Abstract]
Financial Instrument
Financial Instrument [Axis]
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Unvested, Weighted-Average Grant Date Fair Value, Cancelled or forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Number of shares available for future grant
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Payments to Acquire Property, Plant, and Equipment, Total
Purchase of property, plant and equipment
Payments to Acquire Property, Plant, and Equipment
Government-sponsored Enterprise Securities [Member]
US Government-sponsored Enterprises Debt Securities [Member]
Geographical
Geographical [Axis]
Common shares, CHF 0.03 par value, 145,364,335 and 115,172,786 shares authorized at December 31, 2021 and 2020, respectively, 77,170,164 and 74,110,160 shares issued at December 31, 2021 and 2020, respectively 76,989,848 and 73,914,844 shares outstanding at December 31, 2021 and 2020, respectively
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Variable consideration received
Variable Consideration Received
Variable consideration received.
Number of installments for amount payable
Number Of Installments For Amount Payable
Number of installments for amount payable.
Eligible to receive remaining potential future milestone amount
Eligible to Receive Remaining Potential Future Milestones Amount
Eligible to receive remaining potential future milestones amount.
Total liabilities
Liabilities
Cash equivalents and marketable securities, fair value
Cash Equivalents And Available For Sale Debt Securities Fair Value
Cash equivalents and available for sale debt securities fair value.
Schedule of Income (Loss) Before Provision for Income Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Joint Development Agreement [Member]
Joint Development Agreement [Member]
Joint development agreement.
Liabilities
Liabilities [Abstract]
2019 Casebia Agreement [Member]
Two Thousand And Nineteen Casebia Agreement [Member]
Two thousand and nineteen Casebia agreement.
Collaboration Agreement [Member]
Collaboration Agreement [Member]
Collaboration agreement.
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Vesting of restricted shares
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Sublease income
Sublease income
Sublease Income
Date of joint venture agreement
Joint Venture Agreement Date
Joint venture agreement date.
Schedule of Share Capital
Schedule of Stock by Class [Table Text Block]
Research costs
Accrued Research And Development Expense Current
Accrued research and development expense current.
Percentage of partnership interests
Limited Liability Company or Limited Partnership, Members or Limited Partners, Ownership Interest
Milestone payment receivable
Milestone Payment Receivable Inclusive Of Exercise Of Each Exclusive Option
Milestone payment receivable inclusive of exercise of each exclusive option.
Unrealized loss on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Leasehold improvements
Property, Plant and Equipment, Estimated Useful Lives
Depreciation
Deferred Tax Liabilities, Property, Plant and Equipment
Legal Entity
Legal Entity [Axis]
Company contributions toward the plan
Defined Contribution Plan, Employer Discretionary Contribution Amount
Revenue from related party
Revenue from Related Parties
Remaining milestone payment receivable
Remaining milestone payment receivable.
General and Administrative [Member]
General and Administrative Expense [Member]
Certain Options [Member]
Certain Options [Member]
Certain options.
Weighted-Average Remaining Contractual Term, Exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Entity Address, Country
Entity Address, Country
Transaction price
Collaborative And License Arrangement Transaction Price
Collaborative and license arrangement, transaction price.
Casebia Therapeutics Limited Liability Partnership [Member]
Casebia Therapeutics Llp [Member]
Casebia Therapeutics LLP.
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Registered share capital
Common Stock Registered Share Capital
Common stock registered share capital.
Operating lease assets
Deferred Tax Liabilities Operating Lease Assets
Deferred tax liabilities operating lease assets.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Other Liabilities, Current, Total
Other current liabilities
Other Liabilities, Current
City Area Code
City Area Code
Contractual Obligation, Total
Research obligation
Contractual Obligation
Other receivables
Other Receivables
Fair Value of Each Option Issued to Employees Estimated Using Black-Scholes Option-Pricing Model
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Total deferred tax assets
Deferred Tax Assets, Gross
Uncertain tax positions recognized
Significant uncertain tax positions
Uncertain Tax Position Recognized
Uncertain tax position recognized.
Specified Target Option Material Right [Member]
Specified Target Option Material Right [Member]
Specified target option material right.
Net deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
US Treasury Securities [Member]
US Treasury Securities [Member]
Patent Costs
Patent Costs Policy Policy [Text Block]
Patent costs.
Revenue:
Revenues [Abstract]
Change in accounting principle, accounting standards update, adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Reconciliation to amounts within the consolidated balance sheets
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents [Abstract]
Contract with Customer, Liability, Total
Contract liabilities
Contract with Customer, Liability
Commitments and contingencies (Note 8)
Commitments and Contingencies
Schedule of Antidilutive Securities not Include in Computation of Net Income (Loss) per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Finite-Lived Intangible Assets, Net, Ending Balance
Finite-Lived Intangible Assets, Net, Beginning Balance
Finite-Lived Intangible Assets, Net, Total
Intangible assets, net
Finite-Lived Intangible Assets, Net
Common shares sold
Issuance of common shares
Issuance of common shares, net of issuance costs (in shares)
Debt Securities, Available-for-sale, Total
Marketable securities, fair value
Debt Securities, Available-for-sale
Furniture, Fixtures, and Other [Member]
Furniture Fixtures And Other [Member]
Furniture, fixtures, and other.
Cash [Member]
Cash [Member]
Related Party
Related Party [Domain]
Change in accounting principle, accounting standards update, immaterial effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Income Statement [Abstract]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Net cash (used in) provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Property and equipment purchases in accounts payable and accrued expenses
Capital Expenditures Incurred but Not yet Paid
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Selected Quarterly Financial Data (Unaudited)
Quarterly Financial Information [Text Block]
Tax Credit Carryforward, Name
Tax Credit Carryforward, Name [Domain]
Employee-related Liabilities, Current, Total
Payroll and employee-related costs
Employee-related Liabilities, Current
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Total property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Current deferred revenue
Deferred revenue, current
Contract with Customer, Liability, Current
Common Stock, Shares, Issued, Total
Common stock, shares issued
Common Stock, Shares, Issued
New Accounting - Pronouncements Not Yet Adopted
Recent Accounting Pronouncements Not Yet Adopted Policy [Text Block]
Recent accounting pronouncements not yet adopted.
Beta Globin
Beta Globin [Member]
Beta-Globin.
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Unvested, Shares, Cancelled or forfeited
Annual rental payments
Annual Rental Payment
Annual rental payment.
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Deferred Tax Liabilities, Gross, Total
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Basis of Presentation and Use of Estimates
Basis Of Presentation And Use Of Estimates Policy [Text Block]
Basis of presentation and use of estimates.
Marketable securities, amortized cost
Debt Securities, Available-for-sale, Amortized Cost
Operating lease, right-of-use asset
Net lease assets
Operating lease assets
Lease expiration year
Lease Expiration Year
Lease expiration year.
Security Exchange Name
Security Exchange Name
Statistical Measurement
Statistical Measurement [Domain]
Impact of deferred rate change
Effective Income Tax Rate Reconciliation Nondeductible Expense Impact Of Deferred Rate Change
Effective income tax rate reconciliation nondeductible expense impact of deferred rate change.
Deferred income taxes:
Deferred Federal, State and Local, Tax Expense (Benefit) [Abstract]
Other Liabilities, Noncurrent, Total
Other non-current liabilities
Other Liabilities, Noncurrent
Loss from Equity Method Investment [Member]
Loss From Equity Method Investments [Member]
Loss from equity method investments.
ASU 2019-12 [Member]
Accounting Standards Update 2019-12 [Member]
Cash and cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Amount payable under collaboration agreement
Collaborative Arrangement Amount Payable
Collaborative arrangement, amount payable.
Document Period End Date
Document Period End Date
Valuation Allowance [Table]
Valuation Allowance [Table]
Restricted cash
Restricted Cash
Restricted Cash, Noncurrent
Income Statement Location
Income Statement Location [Axis]
Investments
Investments [Domain]
Total
Accrued expenses
Accrued Liabilities, Current
Lease Arrangement
Lease Arrangement [Member]
Lease arrangement.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary of significant accounting policies.
Sales Agreement With Jefferies LLC [Member]
Sales Agreement With Jefferies L L C [Member]
Sales agreement with Jefferies LLC.
Contingencies And Commitments [Line Items]
Contingencies And Commitments [Line Items]
Contingencies and commitments.
Authorized share capital
Common stock, shares authorized
Common Stock, Shares Authorized
Schedule of Aggregate Changes in Gross Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Nonrefundable upfront payment received
Non Refundable Up Front Payment Received
Nonrefundable upfront payment received.
Deferred revenue
Deferred Tax Assets, Deferred Income
Operating lease liabilities, current
Operating lease liabilities
Operating Lease, Liability, Current
Net amortization of premiums and discounts on marketable securities
Accretion (Amortization) of Discounts and Premiums, Investments
Related Party
Related Party [Axis]
Contract with Customer, Asset, after Allowance for Credit Loss, Total
Contract assets
Contract with Customer, Asset, after Allowance for Credit Loss
Reconciliation of net income (loss) to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Anti-dilutive securities not include in computation of net income (loss) per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Cumulative Effect, Period of Adoption
Cumulative Effect, Period of Adoption [Axis]
Vesting
Vesting [Axis]
2019 ATM [Member]
Two Thousand Nineteen At Market Offering [Member]
Two thousand nineteen at-the-market offering.
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Leasehold improvements paid directly by landlord
Leasehold Improvements Paid Directly by Landlord
Leasehold improvements paid directly by landlord.
Restricted cash
Restricted Cash Fair Value Disclosure
Restricted cash fair value disclosure.
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Operating lease liabilities
Deferred Tax Assets Operating Lease Liabilities
Deferred tax assets operating lease liabilities.
Current Fiscal Year End Date
Current Fiscal Year End Date
(Decrease) increase in cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Marketable securities remaining maturities greater than two years
Debt Securities Available For Sale Securities Remaining Maturity Greater Than Three Year
Debt securities available for sale securities remaining maturity greater than three year.
Operating lease costs
Operating Lease, Cost
Accrued Stamp Taxes
Accrued stamp taxes.
Accrued stamp taxes
Other deferred tax assets
Deferred Tax Assets, Other
Lessee, operating lease, existence of option to extend
Lessee, Operating Lease, Existence of Option to Extend [true false]
Revenue recognized
Contract with Customer, Liability, Change in Timeframe, Performance Obligation Satisfied, Revenue Recognized
2019 Option Agreement [Member]
Two Thousand And Nineteen Option Agreement [Member]
Two thousand and nineteen option agreement.
2019 Lease [Member]
Two Thousand And Nineteen Lease [Member]
Two thousand and nineteen Lease.
Payable of stamp taxes related to securities
Payable Of Stamp Taxes Related To Securities
Payable of stamp taxes related to securities.
Equity method investment, ownership percentage
Equity Method Investment, Ownership Percentage
Counterparty Name
Counterparty Name [Axis]
Assets
Assets [Abstract]
Orphan Drug Credit Carryforwards [Member]
Orphan drug credit carryforwards.
Unrecognized tax benefits would favorably impact the effective tax rate if recognized
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Additional interest of percentage
Additional Interest Of Percentage
Additional interest of percentage.
2021 ATM [Member]
Two Thousand Twenty One At Market Offering [Member]
Two thousand twenty one at market offering.
Licensing fees
Accrued License Fees Current
Accrued license fees current.
Equity issuance costs in accounts payable and accrued expenses
Equity Issuance Costs In Accounts Payable And Accrued Expenses
Equity issuance costs in accounts payable and accrued expenses.
Purchase of common stock under ESPP (in shares)
Stock Purchased During Period Shares Employee Stock Purchase Plan
Stock purchased during period shares employee stock purchase plan.
2022
Lessee, Operating Lease, Liability, to be Paid, Year One
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Cash equivalents and marketable securities, gross unrealized gains
Cash Equivalents And Available For Sale Debt Securities Gross Unrealized Gains Before Tax
Cash equivalents and available for sale debt securities gross unrealized gains before tax.
Common shares, par value
Common stock, par value
Common Stock, Par or Stated Value Per Share
Revenue Recognition
Revenue from Contract with Customer [Policy Text Block]
Schedule of (Provision for) Benefit from Income Taxes
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Research credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Investment, Name
Investment, Name [Axis]
Increases for tax positions taken during current period
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Collaborative Arrangement Material Rights Fourth Exclusive License [Member]
Collaborative Arrangement Material Rights Fourth Exclusive License [Member]
Collaborative arrangement material rights fourth exclusive license.
U.S. Domestic State [Member]
State and Local Jurisdiction [Member]
Weighted Average Number of Shares Outstanding, Basic
Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Basic weighted-average common shares outstanding
Beginning balance (in shares)
Ending balance (in shares)
Shares, Outstanding
Investments, Debt and Equity Securities [Abstract]
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Common Stock
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Vertex and Casebia [Member]
Vertex Pharmaceuticals Inc And Casebia [Member]
Vertex Pharmaceuticals Inc and Casebia.
Current Income Tax Expense (Benefit), Total
Total current income taxes
Current Income Tax Expense (Benefit)
Research and Development Expenses
Research and Development Expense, Policy [Policy Text Block]
Percentage of net profits and net losses
Percentage Of Net Profit And Net Losses
Percentage of net profit and net losses.
Summary of Cash Equivalents and Marketable Securities Recorded at Fair Value
Cash, Cash Equivalents and Investments [Table Text Block]
Net income (loss) before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Document Type
Document Type
Vesting
Vesting [Domain]
Operating lease non-cash items:
Operating Lease Non Cash Items [Abstract]
Operating lease non-cash items.
U.S. Domestic Federal [Member]
Domestic Tax Authority [Member]
Reconciliation of Effective Income Tax Rate
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Business Combination, Consideration Transferred, Total
Business combination, consideration transferred
Business Combination, Consideration Transferred
Intangible assets
Deferred Tax Liabilities, Intangible Assets
Non-current operating lease liabilities
Operating lease liabilities, net of current portion
Operating Lease, Liability, Noncurrent
Schedule of Accrued Expenses
Schedule of Accrued Liabilities [Table Text Block]
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Underwritten public offering.
Total current assets
Assets, Current
Weighted-average common shares outstanding:
Weighted Average Common Shares Outstanding Disclosure [Abstract]
Weighted-average common shares outstanding disclosure.
ASC 326 [Member]
Accounting Standards Update 2016-13 [Member]
Estimated standalone selling price for single collaboration
Estimated Standalone Selling Price For Single Collaboration
Estimated standalone selling price for single collaboration.
Outstanding Options [Member]
Stock Options [Member]
Share-based Payment Arrangement, Option [Member]
Federal
Deferred Federal Income Tax Expense (Benefit)
Weighted-Average Remaining Contractual Term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Equity Method Investment, Nonconsolidated Investee
Equity Method Investment, Nonconsolidated Investee [Axis]
Proceeds from Sale and Maturity of Marketable Securities, Total
Maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Income Tax Expense (Benefit), Total
Total income tax (provision) benefit
Provision for income taxes
Income Tax Expense (Benefit)
Deficient amount paid in cash
Deficient Amount Paid Under Collaboration Agreement
Deficient amount paid under collaboration agreement.
Company incorporation date
Entity Incorporation, Date of Incorporation
Leases [Abstract]
Antidilutive Securities
Antidilutive Securities [Axis]
Unvested, Shares, Beginning Balance
Unvested, Shares, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Aggregate Intrinsic Value, Vested or expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Cash equivalents and marketable securities, gross unrealized losses
Cash Equivalents And Available For Sale Debt Securities Gross Unrealized Losses Before Tax
Cash equivalents and available for sale debt securities gross unrealized losses before tax.
Research Collaboration Agreement [Member]
Research Collaboration Agreement [Member]
Research collaboration agreement.
Deferred Tax Assets, Operating Loss Carryforwards, Total
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Issuance of common stock for license agreements (in shares)
Stock Issued During Period, Shares, Treasury Stock Reissued
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Common Stock, Shares, Outstanding
State
Current State and Local Tax Expense (Benefit)
2015 Casebia Agreement [Member]
Two Thousand And Fifteen Casebia Agreement [Member]
Two thousand and fifteen Casebia agreement.
Plan Name
Plan Name [Axis]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Deferred Income Tax Expense (Benefit), Total
Total deferred income taxes
Deferred Income Tax Expense (Benefit)
Operating Expenses
Total operating expenses
Operating expenses
Ownership
Ownership [Domain]
Milestone payment receivable
Milestone Payment Receivable
Milestone payment receivable.
IPO [Member]
IPO [Member]
Net lease cost
Lease, Cost
Financial Instruments
Financial Instruments [Domain]
2020 ATM [Member]
Two Thousand Twenty At Market Offering [Member]
Two thousand twenty at market offering.
Marketable securities, gross unrealized losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Weighted-Average Exercise Price, Outstanding, Beginning Balance
Weighted-Average Exercise Price, Outstanding, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Statutory to US GAAP permanent differences
Effective Income Tax Rate Reconciliation Statutory Permanent Differences
Effective income tax rate reconciliation statutory permanent differences.
Operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Accounting Standards Update [Extensible List]
Accounting Standards Update [Extensible Enumeration]
Other deferred tax liabilities
Deferred Tax Liabilities, Other
Cost sharing expensed relating to patent maintenance, defense and prosecution, incurred
Cost Sharing Expenses Incurred
Cost sharing expenses incurred.
Canton of Zug [Member]
Canton Of Zug [Member]
Canton of Zug.
Right-of-use assets increased through lease modifications and reassessments
Right Of Use Assets Increased Through Lease Modifications And Reassessments
Right-of-use assets increased through lease modifications and reassessments.
Summary of Maturity of Undiscounted Payments Due under Lease Liabilities and Present Value of Those Liabilities
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
2015 Lease [Member]
Two Thousand And Fifteen Lease [Member]
Two thousand and fifteen lease.
Equity Method Investment, Nonconsolidated Investee or Group of Investees [Member]
Equity Method Investment, Nonconsolidated Investee or Group of Investees [Member]
Net income (loss) per common share - diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Diluted net (loss) income per common share
Marketable securities, gross unrealized gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Net (loss) income per common share:
Earnings Per Share [Abstract]
2023
Lessee, Operating Lease, Liability, to be Paid, Year Two
Net income (loss)
Net income (loss)
Net (loss) income
Net Income (Loss) Attributable to Parent
Schedule of Reconciliation of Income Tax Expense Computed at Statutory Corporate Income Tax Rate to Effective Income Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Compensation Related Costs [Abstract]
Cash equivalents, gross unrealized losses
Cash Equivalents Gross Unrealized Losses Before Tax
Cash equivalents gross unrealized losses before tax.
Concentrations of Credit Risk and Off-balance Sheet Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Other Comprehensive Income Location [Domain]
Operating leases, weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Research and Development [Member]
Research and Development Expense [Member]
Document Fiscal Period Focus
Document Fiscal Period Focus
Prepaid expenses and other current assets
Prepaid Expenses And Other Current Assets Fair Value Disclosure
Prepaid expenses and other current assets fair value disclosure.
Accounting Policies [Abstract]
Foreign
Current Foreign Tax Expense (Benefit)
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive income (loss)
Accumulated Other Comprehensive Income (Loss), Net of Tax
Entity Address, Address Line One
Entity Address, Address Line One
Total intrinsic value of stock options exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Share-based compensation, options, outstanding
Shares, Outstanding, Beginning Balance
Shares, Outstanding, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Total current liabilities
Liabilities, Current
Employee Benefit Plans [Member]
Employee Benefit Plans [Member]
Employee benefit plans member.
Net (loss) income
Net income (loss)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss of joint venture
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Commercial Paper [Member]
Commercial Paper [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Title of Individual
Title of Individual [Axis]
Treasury stock, shares
Treasury Stock, Shares, Ending Balance
Treasury Stock, Shares, Beginning Balance
Treasury Stock, Shares, Total
Aggregate Intrinsic Value, Outstanding Balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Total
Lessee, Operating Lease, Liability, to be Paid
Product and Service
Product and Service [Domain]
Schedule of Estimated Useful Lives of Assets
Schedule Of Estimated Useful Lives Of Assets Table [Text Block]
Schedule of estimated useful lives of assets.
Revenues, Total
Collaboration revenue
Revenues
Lease expiration, month and year
Lease Expiration Month And Year
Lease expiration month and year.
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Net cash provided by (used in) operating activities
Net Cash Provided by (Used in) Operating Activities
Number of options exercised under agreement
Number Of Options Exercised Under Agreement
Number of options exercised under agreement.
Equity issuance costs
Equity Issuance Costs
Equity issuance costs.
Total
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Equity Components
Equity Components [Axis]
Summary of Operating Lease Costs Included in Research and Development and General and Administrative Expense, as well as Sublease Income
Lease, Cost [Table Text Block]
Current assets:
Assets, Current [Abstract]
Variable lease costs
Variable Lease, Cost
Purchase of common stock under ESPP
Stock Purchased During Period Value Employee Stock Purchase Plan
Stock purchased during period value employee stock purchase plan.
Entity Registrant Name
Entity Registrant Name
Cash, cash equivalents and marketable securities
Cash Cash Equivalents And Marketable Securities
Cash, cash equivalents and marketable securities.
Schedule of Fair Value of Assets and Liabilities Received
Fair Value, by Balance Sheet Grouping [Table Text Block]
Collaborative arrangement, license rights reacquired by waiving payment owed
Collaborative Arrangement License Rights Reacquired By Waiving Payment Owed
Collaborative arrangement license rights reacquired by waiving payment owed.
Marketable securities maturity period
Marketable Securities Maturity Period
Marketable securities maturity period.
Lessee, operating sublease, existence of option to extend
Lessee, Operating Sublease, Existence of Option to Extend [true false]
Aggregate amount in option exercise payments received
Aggregate Amount In Option Exercise Payments Received Under Collaboration Agreement
Aggregate amount in option exercise payments received under collaboration agreement.
Share Capital
Stockholders' Equity Note Disclosure [Text Block]
Share-based compensation, requisite service period
Share-based Compensation Arrangement by Share-based Payment Award, Award Requisite Service Period
ViaCyte [Member]
Via Cyte [Member]
ViaCyte.
Entity Interactive Data Current
Entity Interactive Data Current
Entity Address, City or Town
Entity Address, City or Town
Number of additional renewal terms
Number Of Additional Renewal Terms
Number of additional renewal terms.
Number of options would not be exercised under agreement
Number Of Options Would Not Be Exercised Under Agreement
Number of options would not be exercised under agreement.
Current income taxes:
Current Federal, State and Local, Tax Expense (Benefit) [Abstract]
2015 Collaboration Agreement [Member]
Two Thousand And Fifteen Collaboration Agreement [Member]
2015 Collaboration Agreement.
Expected term (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Estimated standalone selling price for collaboration agreement
Estimated Standalone Selling Price For Collaboration Agreement
Estimated standalone selling price for collaboration agreement.
Lessee, operating sublease, option to extend
Lessee, Operating Sublease, Option to Extend
Trading Symbol
Trading Symbol
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Incremental Common Shares Attributable to Share-based Payment Arrangements, Total
Effect of potentially dilutive securities
Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements
Investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Fair value of controlling interest obtained
Business Combination Controlling Interest Consideration Fair Value
Business combination, controlling interest, consideration fair value
Present value adjustment
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Local Phone Number
Local Phone Number
ASC 842 [Member]
Accounting Standards Update 2016-02 [Member]
Vertex [Member]
Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member]
Vertex Pharmaceuticals Incorporated And Its Certain Subsidiaries [Member]
Vertex Pharmaceuticals Incorporated and its certain subsidiaries.
Total shareholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Selected Quarterly Financial Data
Quarterly Financial Information [Table Text Block]
Unrecognized tax benefits, gross
Balance at beginning of year
Balance at end of year
Unrecognized Tax Benefits
Operating cash flows used in operating leases
Operating Lease, Payments
Comprehensive (Loss) Income
Comprehensive Income, Policy [Policy Text Block]
Research and Development [Abstract]
Number of remaining options under agreement
Number Of Remaining Options Under Agreement
Number of remaining options under agreement.
Total
Assets, Fair Value Disclosure
Statistical Measurement
Statistical Measurement [Axis]
Entity Small Business
Entity Small Business
Increase (Decrease) in Other Operating Liabilities, Total
Other liabilities, net
Increase (Decrease) in Other Operating Liabilities
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Leases
Lessee, Leases [Policy Text Block]
Option and Grant Plans [Member]
Option And Grant Plans [Member]
Option and grant plans.
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Total
Shares, Cancelled or forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Short-term Debt, Type
Short-term Debt, Type [Domain]
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Schedule of Significant Components of Company's Deferred Tax Assets
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Accrued Liabilities, Current [Abstract]
Impairment of Long-lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Research and Development [Member]
Research Tax Credit Carryforward [Member]
Vesting Percentage on Second Anniversary [Member]
Share-based Payment Arrangement, Tranche Two [Member]
Lease renewal term under each extension option
Lease Renewal Term Under Each Extension Option
Lease renewal term under each extension option.
Common Stock, Voting Rights
Common Stock, Voting Rights
Estimated useful lives of assets
Property, Plant and Equipment, Useful Life
Entity
Entity [Domain]
us-gaap:AccountingStandardsUpdate201409Member
ASC 606 [Member]
Accounting Standards Update 2014-09 [Member]
Balance Sheet Location
Balance Sheet Location [Axis]
Number of shares issued
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period
Co-commercialization Agreement [Member]
Co Commercialization Agreement [Member]
Co-commercialization agreement.
Collaboration Target Options Material Rights Two [Member]
Collaborative Arrangement Material Rights Two [Member]
Collaborative arrangement material rights two.
A&R JDCA [Member]
Amended And Restated Joint Development And Commercialization Agreement [Member]
Amended and restated joint development and commercialization agreement.
Taxes Payable, Current, Total
Accrued tax liabilities
Taxes Payable, Current
Cash equivalents, fair value
Cash Equivalents Fair Value
Cash equivalents fair value.
Impact of Adoption ASC 842 on the Financial Statements
Accounting Standards Update and Change in Accounting Principle [Table Text Block]
Schedule of Financial Assets Measured at Fair Value on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Weighted-Average Exercise Price, Granted
Weighted-average exercise price
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Sale of Stock
Sale of Stock [Domain]
Intellectual property costs
Accrued Intellectual Property Costs Current
Accrued intellectual property costs current.
Equity [Abstract]
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Plan Name
Plan Name [Domain]
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent, Total
Other comprehensive income (loss)
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Class of Stock [Line Items]
Class of Stock [Line Items]
Deferred tax assets:
Components of Deferred Tax Assets [Abstract]
Cost sharing expensed relating to patent maintenance, defense and prosecution, accrued
Cost Sharing Expenses Accrued
Cost sharing expenses accrued.
Income Tax Authority
Income Tax Authority [Axis]
Depreciation, Total
Depreciation expense
Depreciation
Other Current Liabilities [Member]
Other Current Liabilities [Member]
Decrease in valuation allowance
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
State income tax, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Issuance of common shares, value
Issuance of common shares, net of issuance costs
Stock Issued During Period, Value, New Issues
Operating lease liabilities
Operating Lease Liabilities Fair Value Disclosure
Operating lease liabilities fair value disclosure.
Marketable securities unrealized loss, Less than twelve months
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months
Quarterly Financial Information Disclosure [Abstract]
Percentage of research and development costs
Percentage Of Research And Development Costs
Percentage of research and development costs.
Valuation Allowance [Line Items]
Valuation Allowance [Line Items]
Percentage of exchange payment of research and development costs
Percentage Of Exchange Payment Of Research And Development Costs
Percentage of exchange payment of research and development costs.
Operating loss carryforwards expiration period
Operating Loss Carryforwards Expiration Period
Operating Loss carryforwards expiration period.
Reimbursements from research and license agreements
Research And Development Contract Arrangement Reimbursements Received
Research and development contract arrangement reimbursements received.
Notes Payable, Total
Additional amount payable under certain circumstances
Notes Payable
Vertex Pharmaceuticals Inc [Member]
Vertex Pharmaceuticals Inc [Member]
Vertex Pharmaceuticals Inc.
Cash equivalents, amortized cost
Cash Equivalents, at Carrying Value
Share-based Payment Arrangement, Noncash Expense, Total
Equity-based compensation
Share-based Payment Arrangement, Noncash Expense
Prepaid expenses and other current assets
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Summary of Restricted Stock Activity
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
License and Service [Member]
License and Service [Member]
Summary of Stock Option Activity
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Related Party Transactions [Abstract]
Valuation, Market Approach
Valuation, Market Approach [Member]
Unvested Restricted Common Shares [Member]
Unvested Restricted Common Shares [Member]
Unvested restricted common shares.
Federal
Current Federal Tax Expense (Benefit)
Collaboration agreement period
Collaborative Agreement Period
Collaborative agreement period.
Rights Four [Member]
Collaborative Arrangement Material Rights Four [Member]
Collaborative arrangement material rights four.
Shares, Exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Commitments and Contingencies Disclosure [Abstract]
Net assets
Fair Value, Net Asset (Liability)
Right-of-use assets obtained in exchange for operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Unvested, Weighted-Average Grant Date Fair Value, Vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Total assets
Assets
Level 2 [Member]
Fair Value, Inputs, Level 2 [Member]
Leases
Lessee, Operating Leases [Text Block]
Exercise of vested options, net of issuance costs (in shares)
Shares, Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Accrued interest or penalties related to uncertain tax positions
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
2019 Sublease [Member]
Two Thousand And Nineteen Sublease [Member]
Two thousand and nineteen sublease.
Statement [Line Items]
Statement [Line Items]
Total liabilities and shareholders’ equity
Liabilities and Equity
Issuance of common stock for license agreements
Stock Issued During Period, Value, Treasury Stock Reissued
Balance Sheet Location
Balance Sheet Location [Domain]
Payments of stamp taxes related to securities
Payments Of Stamp Taxes Related To Securities
Payments of stamp taxes related to securities.
Property, Plant and Equipment [Abstract]
Dividends, Total
Dividends declared and paid
Dividends
Statement of Cash Flows [Abstract]
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Title of 12(b) Security
Title of 12(b) Security
Comprehensive income (loss)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
2016 Sublease [Member]
Two Thousand And Sixteen Sublease [Member]
Two thousand and sixteen sublease.
Cash equivalents, gross unrealized gains
Cash Equivalents Gross Unrealized Gains Before Tax
Cash equivalents gross unrealized gain before tax.
Level 3 [Member]
Fair Value, Inputs, Level 3 [Member]
Cash paid for amounts included in measurement of lease liabilities:
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Cash paid for amounts included in measurement of lease liabilities.
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Up-front payment received
Up Front Payment Received
Up-front payment received.
Total lease assets
Lease Assets
Lease assets.
Award Type
Award Type [Domain]
Share-based compensation, vesting percentage
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
DMD License [Member]
Duchenne Muscular Dystrophy License [Member]
Duchenne Muscular Dystrophy License.
2019 Collaboration Agreement [Member]
Collaborative Arrangement [Member]
Collaborative Arrangement [Member]
Share-based compensation, options, contractual life
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Deficient amount payable
Deficient Amount Payable Under Collaboration Agreement
Deficient amount payable under collaboration agreement.
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Accounts payable and accrued expenses
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Summary of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Level 1 [Member]
Fair Value, Inputs, Level 1 [Member]
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Vesting of restricted shares (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
2025
Lessee, Operating Lease, Liability, to be Paid, Year Four
Long term deferred taxes, assets
Deferred Tax Assets, Net
Variable consideration adjusted to transaction price
Contract with Customer, Liability, Cumulative Catch-up Adjustment to Revenue, Change in Estimate of Transaction Price
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Restricted Stock [Member]
Restricted Stock [Member]
Total other income, net
Nonoperating Income (Expense)
Corporate Debt Securities [Member]
Corporate Debt Securities [Member]
Weighted-Average Exercise Price, Vested or expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Deferred Tax Liabilities, Net, Total
Long term deferred taxes, liabilities
Deferred Tax Liabilities, Net
Options granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Share-based payment award, number of shares granted
Entity Current Reporting Status
Entity Current Reporting Status
Valuation Approach and Technique
Valuation Approach and Technique [Axis]
Significant Contracts
Collaborative Arrangement Disclosure [Text Block]
Investment Type
Investment Type [Axis]
Payments to Acquire Marketable Securities, Total
Purchases of marketable securities
Payments to Acquire Marketable Securities
Marketable Securities [Table]
Marketable Securities [Table]
Transaction price allocated to remaining performance obligations
Revenue, Remaining Performance Obligation, Amount
Supplemental disclosure of non-cash investing and financing activities
Noncash Investing and Financing Items [Abstract]
Entity Voluntary Filers
Entity Voluntary Filers
Investment, Name
Investment, Name [Domain]
Money Market Funds [Member]
Money Market Funds [Member]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Unvested, Weighted-Average Grant Date Fair Value, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Lessee, operating lease, option to extend
Lessee, Operating Lease, Option to Extend
2018 Plan [Member]
Two thousand and eighteen stock option and incentive plan.
Performance-Based [Member]
Performance Shares [Member]
Net (Loss) Income Per Share Attributable to Common Shareholders
Earnings Per Share, Policy [Policy Text Block]
Switzerland [Member]
SWITZERLAND
Schedule of Stock-Based Compensation Expense
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Rental payments period
Rental Payments Period Under Lease Arrangement
Rental payments period under lease arrangement.
Retirement Benefits [Abstract]
Non-cash consideration expensed upon execution of collaborative agreement
Non Cash Consideration Expensed Upon Execution Of Collaborative Agreement
Non-cash consideration expensed upon execution of collaborative agreement.
Exclusive License [Member]
Exclusive License [Member]
Exclusive license.
Computer Equipment [Member]
Computer Equipment [Member]
State
Deferred State and Local Income Tax Expense (Benefit)
Accumulated Other Comprehensive Income (Loss) [Member]
AOCI Attributable to Parent [Member]
Auditor Firm ID
Other Long-term Liabilities [Member]
Other Noncurrent Liabilities [Member]
Retirement Agreement [Member]
Retirement Agreement [Member]
Retirement agreement.
Income Statement Location
Income Statement Location [Domain]
Agreement description
Agreements Description
Agreements description.
Vesting Percentage on First Anniversary [Member]
Share-based Payment Arrangement, Tranche One [Member]
Auditor Name
Cumulative effect of ASC 606 adoption [Member]
Cumulative Effect, Period of Adoption, Adjustment [Member]
Net income (loss) per common share - basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Basic net (loss) income per common share
Fair value of obligations
Obligations, Fair Value Disclosure
Weighted-Average Exercise Price, Exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Minimum [Member]
Minimum [Member]
Minimum [Member]
Other Comprehensive Income Location [Axis]
Weighted-Average Remaining Contractual Term, Vested or expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Measurement Frequency
Measurement Frequency [Domain]
Exercise of vested options, net of issuance costs
Stock Issued During Period, Value, Stock Options Exercised
Payment to acquire business
Payments to Acquire Businesses, Gross
Grant Revenue [Member]
Grant [Member]
Total fair value of restricted stock vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Milestone termination amount
Milestone Termination Amount
Milestone termination amount.
Summary of Lease Term and Discount Rate
Lessee Weighted Average Remaining Lease Term And Weighted Average Discount Rate Table [Text Block]
Lessee, weighted average remaining lease term and weighted average discount rate.
Unvested, Shares, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Swiss Law [Member]
Swiss Law [Member]
Swiss law.
Exercise of Exclusive Option [Member]
Exercise Of Exclusive Option [Member]
Exercise of exclusive option.
Organization and Operations
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Non-US Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Foreign
Document Annual Report
Document Annual Report
Deferred Tax Assets, Valuation Allowance, Total
Less valuation allowance
Deferred Tax Assets, Valuation Allowance
Waiving of Vertex Material Right [Member]
Waiving Of Vertexs Material Right [Member]
Waiving of Vertex’s material right.
Summary of Lease Assets and Liabilities
Lessee Lease Assets And Liabilities Table [Text Block]
Lessee, lease assets and liabilities.
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised, Total
Proceeds from exercise of options and ESPP contributions, net of issuance costs
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised
Financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash equivalents and marketable securities, amortized cost
Cash Equivalents And Available For Sale Debt Securities Amortized Cost Basis
Cash equivalents and available for sale debt securities amortized cost basis.
Domestic
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Foreign Currency Translation and Transactions
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Entity Filer Category
Entity Filer Category
Income Taxes
Income Tax, Policy [Policy Text Block]
Document Fiscal Year Focus
Document Fiscal Year Focus
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Shares, Vested or expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Construction Work in Process [Member]
Construction in Progress [Member]
Weighted-average grant date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Marketable securities unrealized loss, more than twelve months
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Future Delivery of up to Two Options [Member]
Future Delivery Of Up To Two Options [Member]
Future delivery of up to two options.
Income Taxes
Income Tax Disclosure [Text Block]
2018 ATM [Member]
Two Thousand Eighteen At Market Offering [Member]
Two thousand eighteen at-the-market offering.
Average issue price of common shares
Average Share Price Per Share
Average share price per share.
Fair Value Disclosures [Abstract]
Property and Equipment, net
Property, Plant and Equipment Disclosure [Text Block]
Short-term lease costs
Short-term Lease, Cost
Non-refundable one-time option payment
Non Refundable One Time Payment To Exercise Option
Non refundable one time payment to exercise option.
Maximum [Member]
Maximum [Member]
Maximum [Member]
Bonds or Similar Debt Instruments [Member]
Bonds Or Similar Debt Instruments [Member]
Bonds or similar debt instruments.
Entity Central Index Key
Entity Central Index Key
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Revenue
Revenue from Contract with Customer, Including Assessed Tax
Share-based compensation, options, vested
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares
Payables and Accruals [Abstract]
Tax credit carryforward, expiration year
Tax Credit Carryforward Expiration Year
Tax credit carryforward expiration year.
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component
Equity Component [Domain]
Framingham Lease [Member]
Framingham Lease [Member]
Framingham lease.
Number of exclusive license targets
Number Of Exclusive License Targets
Number of exclusive license targets.
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Collaboration Revenue [Member]
Collaboration Revenue [Member]
Collaboration revenue.
Foreign rate differential
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Income Tax Authority
Income Tax Authority [Domain]
Variable Interest Entities
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
Unrecognized compensation expense, remaining weighted-average period for recognition
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Accruals and reserves
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Marketable Securities
Cash, Cash Equivalents, and Marketable Securities [Text Block]
Non-cash consideration received
Non Cash Consideration Received
Non-cash consideration received.
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Accounts receivable
Increase (Decrease) in Accounts Receivable
Change in accounting principle, accounting standards update, adoption date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Decreases for tax positions taken during current period
Unrecognized Tax Benefits, Decrease Resulting from Current Period Tax Positions
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Number of authorized for issuance
Number of shares authorized
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Laboratory Equipment [Member]
Laboratory Equipment [Member]
Laboratory equipment.
Statement [Table]
Statement [Table]
Operating leases, weighted-average remaining lease term (years)
Operating Lease, Weighted Average Remaining Lease Term
Entity File Number
Entity File Number
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
DM1 R&D Services [Member]
Myotonic Dystrophy Type One R And D Services [Member]
Myotonic Dystrophy Type One R and D Services.
Accumulated Deficit [Member]
Retained Earnings [Member]
Common shares price per share
Shares Issued, Price Per Share
Accounting Standards Update
Accounting Standards Update [Domain]
Accounting Standards Update
Accounting Standards Update [Axis]
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Total revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Issuance costs
Payments of Stock Issuance Costs
Maximum potential payments
Maximum Potential Payments
Maximum potential payments.
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
U.S. federal net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Domestic
Summary of Significant Accounting Policies and Basis of Presentation
Basis of Presentation and Significant Accounting Policies [Text Block]
Current liabilities:
Liabilities, Current [Abstract]
Equity-based Compensation
Share-based Payment Arrangement [Text Block]
A&R Vertex JDCA [Member]
Amended and Restated Vertex Joint Development and Commercialization Agreement [Member]
Amended and restated vertex joint development and commercialization agreement.
Date of formation of joint venture entity
Date Of Formation Of Joint Venture Entity
Date of formation of joint venture entity.
Effect of potentially dilutive securities:
Incremental Weighted Average Shares Attributable to Dilutive Effect [Abstract]
Jurisdiction
Jurisdiction [Axis]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Operating lease liability
Net lease liabilities
Present value of lease liabilities
Total lease liabilities
DM1 License [Member]
Myotonic Dystrophy Type One License [Member]
Myotonic Dystrophy Type One License.
Common Shares [Member]
Common Stock [Member]
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Total property and equipment, gross
Property, Plant and Equipment, Gross
Liability for Uncertainty in Income Taxes, Noncurrent
Uncertain tax positions
Professional fees
Accrued Professional Fees, Current
Entity Public Float
Entity Public Float
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net, Total
Net assets acquired
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net
Other non-current assets
Other Assets, Fair Value Disclosure
Cover [Abstract]
Unvested, Weighted-Average Grant Date Fair Value, Beginning Balance
Unvested, Weighted-Average Grant Date Fair Value, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Asset Class
Asset Class [Axis]
Research credit
Deferred Tax Assets, Tax Credit Carryforwards, Research
Deferred tax liabilities:
Components of Deferred Tax Liabilities [Abstract]
Collaboration Target Options Material Rights Three [Member]
Collaborative Arrangement Material Rights Three [Member]
Collaborative arrangement material rights three.
Statement of Stockholders' Equity [Abstract]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Tenant incentives
Incentive from Lessor
Number of operating segments
Number of Operating Segments
Voting interest Percentage
Variable Interest Entity, Qualitative or Quantitative Information, Ownership Percentage
Share-based Payment Arrangement [Abstract]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary of significant accounting policies.
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contingencies And Commitments [Table]
Contingencies And Commitments [Table]
Contingencies and commitments.
Restricted Stock Unit [Member]
Restricted Stock Units [Member]
Restricted Stock Units (RSUs) [Member]
Equity Method Investment, Nonconsolidated Investee
Equity Method Investment, Nonconsolidated Investee [Domain]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Other
Other Accrued Liabilities, Current
Document Transition Report
Document Transition Report
Weighted-Average Exercise Price, Cancelled or forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
United Kingdom [Member]
UNITED KINGDOM
Short-term Debt, Type
Short-term Debt, Type [Axis]
Extended term of lease expiration
Lessee, Operating Lease, Renewal Term
Foreign
Deferred Foreign Income Tax Expense (Benefit)
Research and Development Expense, Total
Research and development expense
Research and development
Research and Development Expense
Non-current deferred revenue
Deferred revenue, non-current
Contract with Customer, Liability, Noncurrent
Market-Based [Member]
Market Based Vesting Conditions [Member]
Market-based vesting conditions.
Weighted Average Number of Shares Outstanding, Diluted
Diluted
Diluted weighted-average common shares outstanding
Diluted weighted-average common shares outstanding
Partnership outstanding maximum exchange amount
Limited Liability Company L L C Or Limited Partnership L P Outstanding Exchange Amount
Limited liability company LLC or limited partnership LP outstanding exchange amount.
Stock-based compensation expense
Stock-based compensation expense
Share-based Payment Arrangement, Expense
Operating lease assets and liabilities
Increase Decrease In Operating Lease Assets And Liabilities
Increase decrease in operating lease assets and liabilities.
Statement of Financial Position [Abstract]
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Unvested, Shares, Vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Research and development expense with a related party
Research And Development Expense From Related Party
Research and development expense from related party.
Depreciation, Depletion and Amortization, Total
Depreciation and amortization
Depreciation, Depletion and Amortization
Lessee, Operating Lease Cash Flow Payments
Lessee Operating Lease Cash Flow Payments Table [Text Block]
Lessee, operating lease cash flow payments.
2026
Lessee, Operating Lease, Liability, to be Paid, Year Five
Income tax expense at statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Convertible Promissory Note [Member]
Convertible Notes Payable [Member]
Shareholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Decreases for tax positions taken in prior periods
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Equity-Based Compensation Expense
Compensation Related Costs, Policy [Policy Text Block]
Repurchase of treasury shares
Treasury Stock, Value, Acquired, Cost Method
Departing Employee [Member]
Departing Employee [Member]
Departing employee.
Equity method investment
Equity Method Investments
Schedule of Computation of Basic and Diluted Net Income (Loss) per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Non-Exclusive Research License [Member]
Non Exclusive Research License [Member]
Non exclusive research license.
Weighted-Average Exercise Price, Exercised
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Cost sharing percentage on specified costs
Cost Sharing Percentage On Specified Costs
Cost sharing percentage on specified costs.
Key provisions of collaborative agreement description
Key Provisions Of Collaborative Agreement Description
Key provisions of collaborative agreement description.
Ownership
Ownership [Axis]
Changes in:
Increase (Decrease) in Operating Capital [Abstract]
2024
Lessee, Operating Lease, Liability, to be Paid, Year Three
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Payment Arrangement, Percent
Fair value of assets and liabilities
Equity Method Investments, Fair Value Disclosure
Capital reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Lease commencement date
Lease Commencement Date
Lease commencement date.
Accrued expenses and other current liabilities
Accrued Expenses And Other Current Liabilities Fair Value Disclosure
Accrued expenses and other current liabilities fair value disclosure.
Measurement Frequency
Measurement Frequency [Axis]
Award Type
Award Type [Axis]
Comprehensive Loss [Member]
Other Comprehensive Income (Loss) [Member]
Collaboration Target Options [Member]
Collaborative Arrangement Material Rights [Member]
Collaborative arrangement material rights.
Entity Shell Company
Entity Shell Company
Liabilities and Shareholders’ Equity
Liabilities and Equity [Abstract]
401(k) Savings Plan
Retirement Benefits [Text Block]
Number of products
Number Of Products
Number of products.
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Marketable Securities, Total
Marketable securities
Marketable Securities
Net Income (Loss) Per Share Attributable to Common Shareholders
Earnings Per Share [Text Block]
Operating lease assets
Operating Lease Assets Fair Value Disclosure
Operating lease assets fair value disclosure.
Counterparty Name
Counterparty Name [Domain]
Gain from consolidation of Casebia
Gain Loss From Consolidation Of Subsidiary
Gain loss from consolidation of subsidiary.
Repurchase of treasury shares (in shares)
Treasury Stock, Shares, Acquired
Amendment Flag
Amendment Flag
Collaboration Arrangements
Collaborative Arrangement, Accounting Policy [Policy Text Block]
Schedule Of Stock By Class [Table]
Schedule of Stock by Class [Table]
Product and Service
Product and Service [Axis]
Other income (expense):
Nonoperating Income (Expense) [Abstract]
Conditional share capital - Bonds or similar debt instruments
Common Stock Conditional Capital
Common stock conditional capital.
Other income, net
Other Nonoperating Income (Expense), Total
Other (expense) income
Other Nonoperating Income (Expense)
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
New Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Title of Individual
Title of Individual [Domain]
Income (Loss) from Equity Method Investments, Total
Loss from equity method investment in Casebia
Loss from equity method investment
Income (Loss) from Equity Method Investments
Tax credit carryforward amount
Tax Credit Carryforward, Amount
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Nondeductible expenses
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Total unrecognized compensation expense related to stock options
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Aggregate estimated gross proceeds
Estimated Gross Proceeds From Issuance Of Common Stock
Estimated gross proceeds from issuance of common stock.
Marketable Securities, Current, Total
Marketable securities
Marketable Securities, Current
Recurring Basis [Member]
Fair Value, Recurring [Member]
Other Receivables
Other Receivables Policy [Text Block]
Other receivables.
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Other Assets, Noncurrent, Total
Other non-current assets
Other Assets, Noncurrent
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total
Unrealized loss, net
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
ESPP [Member]
2016 Employee Stock Purchase Plan [Member]
Employee Stock [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Accrued property and equipment
Accrued Property And Equipment
Accrued property and equipment.
Geographical
Geographical [Domain]
Aggregate Intrinsic Value, Exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Increases for tax positions taken in prior periods
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Sale of Stock
Sale of Stock [Axis]
Treasury shares, at cost, 180,316 and 195,316 shares at December 31, 2021 and 2020, respectively
Treasury Stock, Value, Ending Balance
Treasury Stock, Value, Beginning Balance
Treasury Stock, Value, Total
Treasury Stock, Value
Fair Value Measurement
Fair Value Disclosures [Text Block]
Cumulative Effect, Period of Adoption
Cumulative Effect, Period of Adoption [Domain]
Total unrecognized compensation expense
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Proceeds from Issuance of Common Stock
Proceeds from issuance of common shares, net of issuance costs
Proceeds from issuance of common shares